Astelin (Azelastine) is a second generation antihistamine nasal spray that has been approved by the U.S. FDA for treating both seasonal allergic rhinitis in adults and children 5 years and older, and nonallergic vasomotor rhinitis in adults and children 12 years and older. Azelastine provides 12 hours of symptom relief and is designed to be used twice a day.
Nonallergic vasomotor rhinitis can produce symptoms similar to allergic rhinitis, such as sneezing, runny nose, nasal congestion, postnasal drip, or cough. However, nonallergic vasomotor rhinitis is caused by exposure to common indoor and outdoor triggers, including strong odors such as tobacco smoke, perfumes, colognes, hairspray, soaps, detergents, cleaners, paint and car exhaust fumes. Weather also can trigger nonallergic vasomotor rhinitis, especially changes in humidity and temperature. Spicy foods and alcohol can trigger allergy-like symptoms such as runny nose, nasal congestion, sneezing, and postnasal drip. Some estimates are that 80% of patients with rhinitis had both allergic and nonallergic symptoms. Interestingly, other second generation antihistamines such as Cetirizine, Fexofenadine, Loratadine etc. are not approved for nonallergic vasomotor rhinitis.
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