Fragrance Products Cause Acute Toxicities in Mice

Research reported by the U.S. National Library of Medicine and the National Institutes of Health in 1998 investigated whether fragrance products can produce acute toxic effects in mammals.

In this important experiment, groups of male Swiss-Webster mice were forced to breathe the emissions of five commercial colognes or toilet water for 1 hour.

The emissions of these fragrance products caused various combinations of:

  • sensory irritation
  • pulmonary irritation
  • decreases in expiratory airflow velocity
  • neurotoxicity

Neurotoxicity was more severe after mice were repeatedly exposed to the fragrance products.

Mice are mammals, just like us. If you have experienced headaches or other symptoms from exposure to perfume, it's no accident and you should take it seriously. Avoiding chemicals that you react to badly is important for continued good health.


National Institutes of Health
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