Many studies have demonstrated a link between H. pylori infection and gastric cancers (3-7). In 1994, the International Agency for Research on Cancer (IARC) classified H. pylori as a carcinogen, or cancer-causing agent, despite conflicting results at the time.
Since then, colonization of the stomach with H. pylori has been increasingly accepted as an important risk factor for gastric cancers. However, this association varies by region of the stomach. In 2001, a combined analysis of 12 H. pylori and gastric cancer studies estimated that the risk of non-cardia gastric cancer was nearly six times higher for H. pylori-infected people than for uninfected people (3). Data show that infection with H. pylori plays an important role in the development of non-cardia gastric cancer, but its association with gastric cardia cancer is less clear.
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